POD (Point of Departure)
At a glance: The dose where extrapolation toward human-relevant exposures begins.
The Point of Departure is the point on a dose–response curve that marks the start of low-dose extrapolation. It may be a NOAEL or LOAEL, but ideally is established by Benchmark Dose modeling of the experimental data. 32 A NOAEL or LOAEL used as the Point of Departure is then adjusted with uncertainty factors that account for limitations in the data. 32 Points of Departure for thousands of chemicals are compiled in ToxValDB.